Remdesivir has come as a hopeful word for the world standing in the face of the terrible crisis of Corona. Actually, the drug Remdesivir of the US pharmaceutical company Gilead Sciences Inc is being seen as an alternative treatment for corona infection. On Wednesday, on behalf of Gilead, it has been said that the third phase of Remdesivir trial has also yielded positive results. Significantly, people were eagerly waiting for the results of the third phase of this medicine.
How have the tests done
Remdesivir has also been performed on in vitro (test tubes) and in vivo (body tests) test animals. Testing of this drug on MERS and SARS in animals has been successful. The corona virus is also part of the family of these diseases. The company says that it was only after testing on animals that we realized that this drug can be used to treat corona.
The company has said that on March 22, there has been a demand to send Remdesivir for compassionate-use. compassionate-use is said to be the treatment that doctors use but it has not been completely tested for the disease. Doctors use it when there is no option of therapy during treatment.
Remdesivir has been used to treat corona under compassionate-use programme. This was done on those patients who were not being treated with authorized medicines. The company says that there was a flood of demand for this drug under compassionate use.
orphan drug status
On March 23, Remdesivir was given orphan drug status by the US Department of Food and Drug Administration. This status is given to medicines which show the potential ability to cure a disease. They are called orphan or orphans because their commercial production is halted and government support is needed for this. Significantly, Remdesivir is used in the treatment of Ebola epidemic. Because of this status, the company Gilead Sciences will get many concessions. Such as the monopoly of making medicine in the market for seven years. Also, there is an exemption in tax which can be used to develop medicine.
Third stage trial
The company has stated through a press release, 'Gilead is working closely with global health institutions in ongoing experiments on remdesivir to make the corona virus drug.' Significantly, Gilead has started the third phase clinical trial of this drug. The drug has been tested on hundreds of sick to know the effect of remdesivir. According to one statistic, the drugs that normally go into the third stage test are successful. The results of the third phase were said to come in the last of April. Now the company says that it has got positive data. Soon the company will be in a position to give more information on this.
Price will matter for India
After coming into the market commercially, the price of this medicine will matter a lot. Especially for a country like India. It is possible that Gilead can find a local partner in India for this. So that this medicine can be provided in India at reasonable prices.
The drug Remdesivir was discovered in the mid-2010s. Initially, tests done on animals had proved that this drug would work accurately in the treatment of Ebola. But during the third phase of a major trial in the Democratic Republic of Congo, it was found that this drug was not that effective in curing Ebola completely. But now due to Corona's meeting with Sars and Mars, it is believed that this drug will prove effective in the treatment of Corona. Researchers believe that after the Phase III trial, the US Department of Food and Drug Administration will be quick to approve the drug. As it did in 1987 in the case of azidothymidine- AZT, a drug made with HIV / AIDS. But now everything depends on the results of the third phase.
How have the tests done
Remdesivir has also been performed on in vitro (test tubes) and in vivo (body tests) test animals. Testing of this drug on MERS and SARS in animals has been successful. The corona virus is also part of the family of these diseases. The company says that it was only after testing on animals that we realized that this drug can be used to treat corona.
The company has said that on March 22, there has been a demand to send Remdesivir for compassionate-use. compassionate-use is said to be the treatment that doctors use but it has not been completely tested for the disease. Doctors use it when there is no option of therapy during treatment.
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Remdesivir has been used to treat corona under compassionate-use programme. This was done on those patients who were not being treated with authorized medicines. The company says that there was a flood of demand for this drug under compassionate use.
Single Arm Trial Results
Two groups are used in the first and second phase trials of medicines, whereas in the single arm trial phase of remidesivir, instead of forming two groups, the drug is tested randomly on people. That is, in the first two phases there was a control and a therapy experimental group. Both groups suffer from the same disease. The first group is given medicine while the second group is not given medicine. The rest of the atmosphere is similar for both groups. After a fixed period, the difference in the health of the two groups is evaluated. If there is a difference in the therapy group, then it is assumed that the medicine remains effective. And when this drug becomes effective, then it is kept in a third phase trial where there is no control group. It is used in a large way in a random way. This is called single arm trial. The results of remidesivir have come positive in single arm trial after two phases.
orphan drug status
On March 23, Remdesivir was given orphan drug status by the US Department of Food and Drug Administration. This status is given to medicines which show the potential ability to cure a disease. They are called orphan or orphans because their commercial production is halted and government support is needed for this. Significantly, Remdesivir is used in the treatment of Ebola epidemic. Because of this status, the company Gilead Sciences will get many concessions. Such as the monopoly of making medicine in the market for seven years. Also, there is an exemption in tax which can be used to develop medicine.
Third stage trial
The company has stated through a press release, 'Gilead is working closely with global health institutions in ongoing experiments on remdesivir to make the corona virus drug.' Significantly, Gilead has started the third phase clinical trial of this drug. The drug has been tested on hundreds of sick to know the effect of remdesivir. According to one statistic, the drugs that normally go into the third stage test are successful. The results of the third phase were said to come in the last of April. Now the company says that it has got positive data. Soon the company will be in a position to give more information on this.
Price will matter for India
After coming into the market commercially, the price of this medicine will matter a lot. Especially for a country like India. It is possible that Gilead can find a local partner in India for this. So that this medicine can be provided in India at reasonable prices.
The drug Remdesivir was discovered in the mid-2010s. Initially, tests done on animals had proved that this drug would work accurately in the treatment of Ebola. But during the third phase of a major trial in the Democratic Republic of Congo, it was found that this drug was not that effective in curing Ebola completely. But now due to Corona's meeting with Sars and Mars, it is believed that this drug will prove effective in the treatment of Corona. Researchers believe that after the Phase III trial, the US Department of Food and Drug Administration will be quick to approve the drug. As it did in 1987 in the case of azidothymidine- AZT, a drug made with HIV / AIDS. But now everything depends on the results of the third phase.
